With Paul Rudd as Sterling Archer, Aisha Tyler as Lana (duh), Melissa McCarthy as Pam, H. Jon Benjamin as Krieger, etc...
Also it should be directed by either JJ Abrams or Quinton Tarantino.
That's right, a superhero movie where the super isn't the main character, but his actions are seen from the perspective of his BFF/GF Lois Lane. Lois is such an interesting character, it'd be awesome to see a movie that focuses on what's going on in her life. Also, it should be written and produced by James Cameron and it must star Lucy Liu as Lois.
That's right, a James Bond, Mission Impossible mash up movie. I don't even know who should direct that... maybe Christopher Nolan? I don't know, but it would be amazing.